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T cell signalling[edit]

The T cell receptor signalling pathway is described in much more detail here than it is in the T cell receptor article. I would like to add some more information about T cell receptor signalling and antigen discrimination models. Is it better to do this in this article or in the T cell receptor article? Huhny (talk) 12:53, 20 November 2019 (UTC)[reply]

I noticed as well that T cell activation or T cell signalling is described multiple times in different articles (Naive T cell, T Helper cell, T cell receptor, Cytotoxic T cell and even in Lck), in different degrees of detail. It might be good moving all the molecular details of the pathway to the T cell receptor and put a link to it in all other articles).Huhny (talk) 13:18, 20 November 2019 (UTC)[reply]

Purpose of T-cells[edit]

The article has great depth on types of different T-cells, their development, etc, but a little more "why" rather than "how" and "what" would be great. Even one sentence in the summary would go a long way, distinguishing their role from that of B-cells, for instance. I'd be happy to take a crack at it, but it's probably better done by a true subject matter expert — Preceding unsigned comment added by Rockfox212 (talkcontribs) 13:00, 2 August 2016 (UTC)[reply]

Hyphen or not?[edit]

Throughout the article the term is spelled without a hyphen (T cell), except in the accompanying image for T cell activation, where it's inconsistently spelled "T-cell" and "T cell" - Can someone clarify the usage here? Is with or without hyphen preferred? Should there be a difference for hyphenated adejctives, as in "T-cell activation"?

Thanks, 14:30, 10 September 2007 (UTC)[reply]

It's not really a set phrase, so rules are as for normal hyphen usage. I'd just go with whatever makes sense at the time. Unless it's unclear that the "cell" refers to the "T", I'd stick with "T cell". But in some cases, as with "T-cell activation", where, to the non-specialist, there is the potential for confusion as to what is happening, I'd use a hyphen. Consult a copy of Fowler's! Kantokano 15:15, 10 September 2007 (UTC)[reply]

Thanks for clarifying! 16:17, 21 September 2007 (UTC)[reply]

According to National Cancer Institute word style list there is hyphen when it is used as adjective, e.g. "T-cell lymphoma", otherwise when used as a noun it is written as "T cell". — Preceding unsigned comment added by (talk) 09:18, 22 October 2014 (UTC)[reply]

That is the normal hyphenation rule in English. If "T cell" stands on its own as a noun phrase, then no hyphen is required. If "T cell" together modifies another noun (phrase), then a hyphen should be used, such as in "T-cell activation" or "T-cell lymphoma". --JorisvS (talk) 10:54, 22 October 2014 (UTC)[reply]

You can use either, some research scientists use the hyphenated version in their papers, in order to reduce the number of words due to a word limit. — Preceding unsigned comment added by (talk) 13:39, 5 August 2016 (UTC)[reply]

Both "t cell" and "t-cell" are correct. The former is a noun, and the latter is an adjective. So "T cells interact with t-cell receptors" is a grammatically correct sentence. — Preceding unsigned comment added by (talk) 17:20, 6 November 2019 (UTC)[reply]

Should mention MAIT cells[edit]

Since 2009 there has been discussion of mucosal-associated invariant T cells which seem to be activated by molecules presented by MR1 on antigen presenting cells. Should at least mention them here, then give them their own article. eg MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. 2009, [http://www.nature.com/icb/journal/v88/n8/full/icb2010104a.html Innate T cells detect bacteria. Bacteria, mucosal-associated invariant T cells and MR1. 2010], MR1 presents microbial vitamin B metabolites to MAIT cells. 2012 - Rod57 (talk) 03:12, 1 December 2012 (UTC)[reply]

The problem is the balance between making a truly comprehensive article and a readable one - I've been trying for a while to stop this article drifting off into the latest and strangest subset and to keep it general and not involve every paper someone has read and decided is important. It's probably worth waiting until these cells have been better outlined before adding them. --Kantokano (talk) 06:06, 3 January 2013 (UTC)[reply]

Are they outlined enough yet ? - eg. Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. - Rod57 (talk) 13:16, 20 April 2015 (UTC)[reply]

Consistent capitalization[edit]

If "T-sub-H" and "T-sub-h" refer to the same object, the article should consistently use one of the two conventions. Same for "T-sub-c" and "T-sub-C". If they do not refer to the same object, the article should specify what a "T-sub-h" cell is.

No mention of T-cell immunity[edit]

Could it be explained or linked to somehow ? - Rod57 (talk) 13:03, 20 April 2015 (UTC)[reply]

Perhaps we could say : T-cell immunity is a type of Cell-mediated immunity involving Cytotoxic T cells ? - Rod57 (talk) 22:37, 10 February 2016 (UTC)[reply]

Genetic Engineering[edit]

Hello everyone, I added a genetic engineering section as human T cell genome engineering is starting to take off in 2015. — Preceding unsigned comment added by Westernmgene (talkcontribs) 03:11, 28 September 2015 (UTC)[reply]

Not helpful yet. Does not say what type of T cell, what the changes were, or if/how it relates to Chimeric antigen receptor. - Rod57 (talk) 22:51, 10 February 2016 (UTC)[reply]

Why only CD4+ T cell activation described[edit]

The large Signalling/activation section only seems to mention CD4+ cells (~=T helper cells). Could move this section to T helper cell ? Article only briefly mentions activation of other T cell types. - Rod57 (talk) 21:52, 10 February 2016 (UTC)[reply]

Other summaries of T cell activation[edit]

Naive T cell#Activation - Rod57 (talk) 23:01, 23 February 2016 (UTC)[reply]

"T cell" or "T-cell"? We should pick one and stick with it ….[edit]

Doorland Medical Dictionary hyphenates this term Source: https://www.dorlandsonline.com/dorland/iniSearch?searchterm=t-cell&searchtype=Within+Terms+and+in+Definitions

But a look at recently published medical journal articles shows that both "T-cell" and "T cell" are used.

My feeling is that, whichever is preferred, the article should pick one of these conventions and use it consistently throughout. It may be that the hyphenated term is appearing in the links, which may need to be reviewed and revised.

PeacefulPlanet3 (talk) 00:51, 6 June 2019 (UTC)[reply]


This article is missing a section on the History of the T-cell. Who discovered it? When? What are major milestones in research regarding it? Omegastar (talk) 16:37, 16 April 2020 (UTC)[reply]

Very true. There are some references in the History section for Thymus, mentioning Jacques Miller's work. Perhaps a good place to start? IvanStepaniuk (talk) 13:17, 19 December 2022 (UTC)[reply]